Asset Details
Do you wish to reserve the book?
Avr4 promotes Cf‐4 receptor‐like protein association with the BAK1/SERK3 receptor‐like kinase to initiate receptor endocytosis and plant immunity
Hey, we have placed the reservation for you!
By the way, why not check out events that you can attend while you pick your title.
Oops! Something went wrong.
Looks like we were not able to place the reservation. Kindly try again later.
Are you sure you want to remove the book from the shelf?
Avr4 promotes Cf‐4 receptor‐like protein association with the BAK1/SERK3 receptor‐like kinase to initiate receptor endocytosis and plant immunity
Do you wish to request the book?
Avr4 promotes Cf‐4 receptor‐like protein association with the BAK1/SERK3 receptor‐like kinase to initiate receptor endocytosis and plant immunity
Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy
We have requested the book for you!
Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.
Oops! Something went wrong.
Looks like we were not able to place your request. Kindly try again later.
Journal Article
Avr4 promotes Cf‐4 receptor‐like protein association with the BAK1/SERK3 receptor‐like kinase to initiate receptor endocytosis and plant immunity
2016
Overview
The first layer of plant immunity is activated by cell surface receptor‐like kinases (RLKs) and proteins (RLPs) that detect infectious pathogens. Constitutive interaction with the SUPPRESSOR OF BIR1 (SOBIR1) RLK contributes to RLP stability and kinase activity. As RLK activation requires transphosphorylation with a second associated RLK, it remains elusive how RLPs initiate downstream signaling. We employed live‐cell imaging, gene silencing and coimmunoprecipitation to investigate the requirement of associated kinases for functioning and ligand‐induced subcellular trafficking of Cf RLPs that mediate immunity of tomato against Cladosporium fulvum. Our research shows that after elicitation with matching effector ligands Avr4 and Avr9, BRI1‐ASSOCIATED KINASE 1/SOMATIC EMBRYOGENESIS RECEPTOR KINASE 3 (BAK1/SERK3) associates with Cf‐4 and Cf‐9. BAK1/SERK3 is required for the effector‐triggered hypersensitive response and resistance of tomato against C. fulvum. Furthermore, Cf‐4 interacts with SOBIR1 at the plasma membrane and is recruited to late endosomes upon Avr4 trigger, also depending on BAK1/SERK3. These observations indicate that RLP‐mediated resistance and endocytosis require ligand‐induced recruitment of BAK1/SERK3, reminiscent of BAK1/SERK3 interaction and subcellular fate of the FLAGELLIN SENSING 2 (FLS2) RLK. This reveals that diverse classes of cell surface immune receptors share common requirements for initiation of resistance and endocytosis.
Publisher
Academic Press,New Phytologist Trust,Wiley Subscription Services, Inc,Wiley
Subject
Arabidopsis Proteins - metabolism
/ Cf‐4 receptor‐like protein (RLP)
/ Fungal Proteins - metabolism
/ Immunity
/ Kinases
/ Ligands
/ phosphotransferases (kinases)
/ Plants, Genetically Modified
/ Protein Serine-Threonine Kinases - metabolism
/ Proteins
/ Receptors, Cell Surface - metabolism
/ Solanum lycopersicum - immunology
/ Solanum lycopersicum - microbiology
/ Tomatoes
