Asset Details
Do you wish to reserve the book?
The ZEB/miR-200 feedback loop-a motor of cellular plasticity in development and cancer?
Hey, we have placed the reservation for you!
By the way, why not check out events that you can attend while you pick your title.
Oops! Something went wrong.
Looks like we were not able to place the reservation. Kindly try again later.
Are you sure you want to remove the book from the shelf?
The ZEB/miR-200 feedback loop-a motor of cellular plasticity in development and cancer?
Do you wish to request the book?
The ZEB/miR-200 feedback loop-a motor of cellular plasticity in development and cancer?
Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy
We have requested the book for you!
Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.
Oops! Something went wrong.
Looks like we were not able to place your request. Kindly try again later.
Journal Article
The ZEB/miR-200 feedback loop-a motor of cellular plasticity in development and cancer?
2010
Overview
Epithelial‐to‐mesenchymal transition (EMT) is a fundamental process in development and disease. Zinc‐finger enhancer binding (ZEB) transcription factors (ZEB1 and ZEB2) are crucial EMT activators, whereas members of the miR‐200 family induce epithelial differentiation. They are reciprocally linked in a feedback loop, each strictly controlling the expression of the other. Now data show that EMT not only confers cellular motility, but also induces stem‐cell properties and prevents apoptosis and senescence. Thus the balanced expression of ZEB factors and miR‐200 controls all these processes. We therefore propose that the ZEB/miR‐200 feedback loop is the molecular motor of cellular plasticity in development and disease, and in particular is a driving force for cancer progression towards metastasis by controlling the state of cancer stem cells.
New data show that epithelial to mesenchymal transition induces stem cell properties and prevents apoptosis and senescence. Zinc finger enhancer binding transcription factors are crucial EMT activators, suggesting that the ZEB/miR‐200 feedback loop is the molecular motor of cellular plasticity in development and disease.
Publisher
John Wiley & Sons, Ltd,Nature Publishing Group UK,Springer Nature B.V,Nature Publishing Group
Subject
/ Cancer
/ EMBO11
/ EMBO24
/ EMT
/ Epithelial-Mesenchymal Transition - physiology
/ Feedback
/ Gene Expression Regulation, Neoplastic
/ Homeodomain Proteins - metabolism
/ Humans
/ miR-200
/ Repressor Proteins - metabolism
/ Review
/ stemness
/ Transcription Factors - metabolism
/ ZEB1
