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Mitochondria in innate immunity
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Journal Article
Mitochondria in innate immunity
2011
Overview
Mitochondria are cellular organelles involved in host‐cell metabolic processes and the control of programmed cell death. A direct link between mitochondria and innate immune signalling was first highlighted with the identification of MAVS—a crucial adaptor for RIGI‐like receptor signalling—as a mitochondria‐anchored protein. Recently, other innate immune molecules, such as NLRX1, TRAF6, NLRP3 and IRGM have been functionally associated with mitochondria. Furthermore, mitochondrial alarmins—such as mitochondrial DNA and formyl peptides—can be released by damaged mitochondria and trigger inflammation. Therefore, mitochondria emerge as a fundamental hub for innate immune signalling.
Mitochondria control host cell metabolic processes and apoptosis. In addition, they are emerging as crucial hubs for innate immune signalling. Several key innate immune mediators are functionally associated with these organelles, and mitochondrial alarmins can trigger inflammation.
Publisher
John Wiley & Sons, Ltd,Nature Publishing Group UK,Springer Nature B.V,Nature Publishing Group
Subject
Adaptor Proteins, Signal Transducing - immunology
/ Adaptor Proteins, Signal Transducing - metabolism
/ Animals
/ Cells
/ EMBO19
/ EMBO23
/ EMBO24
/ Humans
/ MAVS
/ Mitochondrial Proteins - genetics
/ Mitochondrial Proteins - immunology
/ Mitochondrial Proteins - metabolism
/ pathogen
/ Peptides
/ Review
