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Decoding protein modifications using top-down mass spectrometry
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Journal Article
Decoding protein modifications using top-down mass spectrometry
2007
Overview
Top-down mass spectrometry is an emerging technology which strives to preserve the post-translationally modified forms of proteins present
in vivo
by measuring them intact, rather than measuring peptides produced from them by proteolysis. The top-down technology is beginning to capture the interest of biologists and mass spectrometrists alike, with a main goal of deciphering interaction networks operative in cellular pathways. Here we outline recent approaches and applications of top-down mass spectrometry as well as an outlook for its future.
Publisher
Nature Publishing Group US,Nature Publishing Group
