Asset Details
Do you wish to reserve the book?
Macrophages are important mediators of either tumor- or inflammation-induced lymphangiogenesis
Hey, we have placed the reservation for you!
By the way, why not check out events that you can attend while you pick your title.
Oops! Something went wrong.
Looks like we were not able to place the reservation. Kindly try again later.
Are you sure you want to remove the book from the shelf?
Macrophages are important mediators of either tumor- or inflammation-induced lymphangiogenesis
Do you wish to request the book?
Macrophages are important mediators of either tumor- or inflammation-induced lymphangiogenesis
Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy
We have requested the book for you!
Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.
Oops! Something went wrong.
Looks like we were not able to place your request. Kindly try again later.
Journal Article
Macrophages are important mediators of either tumor- or inflammation-induced lymphangiogenesis
2012
Overview
The lymphatic system provides important functions for tissue fluid homeostasis and immune response. Lymphangiogenesis, the formation of new lymphatics, comprises a series of complex cellular events in vitro or in vivo, e.g., proliferation, differentiation, and sprouting. Recent evidence has implied that macrophages act as a direct structural contributor to lymphatic endothelial walls or secret VEGF-C/-D and VEGF-A to initiate lymphangiogenesis in inflamed or tumor tissues. Bone marrow-derived macrophages are versatile cells that express different functional programs in response to exposure to microenvironmental signals, and can be identified by specific expression of a number of proteins, F4/80, CD11b, and CD68. Several causative factors, e.g., NF-κB, IL-1β, TNF-α, SDF-1, M-CSF, especially TonEBP/VEGF-C signaling, may be actively involved in macrophage-induced lymphangiogenesis. Alteration of macrophage phenotype and function has a profound effect on the development and progression of inflammation and malignancy, and macrophage depletion for controlling lymphangiogenesis may provide a novel approach for prevention and treatment of lymphatic-associated diseases.
Publisher
SP Birkhäuser Verlag Basel,Springer Nature B.V
Subject
/ Animals
/ Biomedical and Life Sciences
/ Cell Adhesion Molecules - physiology
/ Cell Adhesion Molecules, Neuronal - physiology
/ Cells
/ Humans
/ Inflammation - physiopathology
/ Lectins, C-Type - physiology
/ Macrophage colony-stimulating factor
/ Mannose-Binding Lectins - physiology
/ Receptors, Cell Surface - physiology
/ Receptors, CXCR4 - physiology
/ Receptors, Lymphocyte Homing - physiology
/ Review
/ Toll-Like Receptor 4 - physiology
/ Tumors
/ Vascular endothelial growth factor
/ Vascular endothelial growth factor C
/ Vascular Endothelial Growth Factor C - physiology
/ Vascular Endothelial Growth Factor Receptor-3 - physiology
