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Interactions between VEGFR and Notch signaling pathways in endothelial and neural cells
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Interactions between VEGFR and Notch signaling pathways in endothelial and neural cells
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Interactions between VEGFR and Notch signaling pathways in endothelial and neural cells
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Journal Article
Interactions between VEGFR and Notch signaling pathways in endothelial and neural cells
2013
Overview
Notch cell interaction mechanism governs cell fate decisions in many different cell contexts throughout the lifetime of all Metazoan species. It links the fate of one cell to that of its neighbors through cell-to-cell contacts, and binding of Notch receptors expressed on one cell to their membrane bound ligands on an adjacent cell. Environmental cues, such as growth factors and extracellular matrix molecules, superimpose a dynamic regulation on this canonical Notch signaling pathway. In this review, we will focus on Notch signaling in the vertebrate vascular and nervous systems and examine its role in angiogenesis, neurogenesis, and neurovascular interactions. We will also highlight the molecular relationships of the Notch pathway with vascular endothelial growth factors (VEGFs) and their high-affinity tyrosine kinase VEGF receptors, key regulators of both angiogenesis and neurogenesis.
Publisher
SP Birkhäuser Verlag Basel,Springer Nature B.V
Subject
/ Biomedical and Life Sciences
/ Endothelial Cells - cytology
/ Endothelial Cells - metabolism
/ Humans
/ Kinases
/ Metazoa
/ Neovascularization, Pathologic - metabolism
/ Neurons
/ Receptors, Notch - metabolism
/ Receptors, Vascular Endothelial Growth Factor - metabolism
/ Tyrosine
/ Vascular endothelial growth factor
/ Vascular endothelial growth factor receptors
