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Molecular adaptations underlying high-frequency hearing in the brain of CF bats species
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Molecular adaptations underlying high-frequency hearing in the brain of CF bats species
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Molecular adaptations underlying high-frequency hearing in the brain of CF bats species
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Journal Article
Molecular adaptations underlying high-frequency hearing in the brain of CF bats species
2024
Overview
Background
The majority of bat species have developed remarkable echolocation ability, especially for the laryngeally echolocating bats along with high-frequency hearing. Adaptive evolution has been widely detected for the cochleae in the laryngeally echolocating bats, however, limited understanding for the brain which is the central to echolocation signal processing in the auditory perception system, the laryngeally echolocating bats brain may also undergo adaptive changes.
Result
In order to uncover the molecular adaptations related with high-frequency hearing in the brain of laryngeally echolocating bats, the genes expressed in the brain of
Rhinolophus ferrumequinum
(CF bat) and
Myotis pilosus
(FM bat) were both detected and also compared. A total of 346,891 genes were detected and the signal transduction mechanisms were annotated by the most abundant genes, followed by the transcription. In hence, there were 3,088 DEGs were found between the two bat brains, with 1,426 highly expressed in the brain of
R. ferrumequinum
, which were significantly enriched in the neuron and neurodevelopmental processes. Moreover, we found a key candidate hearing gene,
ADCY1
, playing an important role in the
R. ferrumequinum
brain and undergoing adaptive evolution in CF bats.
Conclusions
Our study provides a new insight to the molecular bases of high-frequency hearing in two laryngeally echolocating bats brain and revealed different nervous system activities during auditory perception in the brain of CF bats.
Publisher
BioMed Central,BioMed Central Ltd,Springer Nature B.V,BMC
Subject
