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Distinct Cross-reactive B-Cell Responses to Live Attenuated and Inactivated Influenza Vaccines
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Distinct Cross-reactive B-Cell Responses to Live Attenuated and Inactivated Influenza Vaccines
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Journal Article
Distinct Cross-reactive B-Cell Responses to Live Attenuated and Inactivated Influenza Vaccines
2014
Overview
Background. The immunological bases for the efficacies of the 2 currently licensed influenza vaccines, live attenuated influenza vaccine (LAIV) and inactivated influenza vaccine (IIV), are not fully understood. The goal of this study was to identify specific B-cell responses correlated with the known efficacies of these 2 vaccines. Methods. We compared the B-cell and antibody responses after immunization with 2010/2011 IIV or LAIV in young adults, focusing on peripheral plasmablasts 6-8 days after vaccination. Results. The quantities of vaccine-specific plasmablasts and plasmablast-derived polyclonal antibodies (PPAbs) in IIV recipients were significantly higher than those in LAIV recipients. No significant difference was detected in the avidity of vaccine-specific PPAbs between the 2 vaccine groups. Proportionally, LAIV induced a greater vaccinespecific immunoglobulin A plasmablast response, as well as a greater plasmablast response to the conserved influenza nuclear protein, than IIV. The cross-reactive plasmablast response to heterovariant strains, as indicated by the relative levels of cross-reactive plasmablasts and the cross-reactive PPAb binding reactivity, was also greater in the LAIV group. Conclusions. Distinct quantitative and qualitative patterns of plasmablast responses were induced by LAIV and IIV in young adults; a proportionally greater cross-reactive response was induced by LAIV.
Publisher
Oxford University Press
Subject
/ Adult
/ Antibodies, Viral - immunology
/ Biological and medical sciences
/ Cross Reactions - immunology
/ Fundamental and applied biological sciences. Psychology
/ H1N1 subtype influenza A virus
/ Humans
/ Immunity, Cellular - immunology
/ Immunity, Humoral - immunology
/ Immunoglobulin A - immunology
/ Influenza Vaccines - immunology
/ Influenza Vaccines - pharmacology
/ Influenza, Human - immunology
/ Influenza, Human - prevention & control
/ Vaccines, Attenuated - immunology
/ Vaccines, Attenuated - pharmacology
/ Vaccines, Inactivated - immunology
/ Vaccines, Inactivated - pharmacology
/ VIRUSES
