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Microtubule Dynamics in vitro are Regulated by the Tubulin Isotype Composition
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Microtubule Dynamics in vitro are Regulated by the Tubulin Isotype Composition
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Journal Article
Microtubule Dynamics in vitro are Regulated by the Tubulin Isotype Composition
1994
Overview
The growing and shortening dynamics of individual bovine brain microtubules at their plus ends at steady state in vitro, assembled from isotypically pure αβII, αβIII, or αβIVtubulin dimers, were determined by differential interference contrast video microscopy. Microtubules assembled from the purified αβIIIisotype were considerably more dynamic than microtubules made from the αβIIor αβIVisotypes or from unfractionated phosphocellulose-purified tubulin. Furthermore, increasing the proportion of the αβIIisotype in a mixture of the αβIIand αβIIIisotypes suppressed microtubule dynamics, demonstrating that microtubule dynamics can be influenced by the tubulin isotype composition. The data support the hypothesis that cells might determine the dynamic properties and functions of its microtubules in part by altering the relative amounts of the different tubulin isotypes.
