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Mesenchymal–epithelial transition in development and reprogramming
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Mesenchymal–epithelial transition in development and reprogramming
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Journal Article
Mesenchymal–epithelial transition in development and reprogramming
2019
Overview
During organogenesis, epithelial cells can give rise to mesenchymal cells through epithelial–mesenchymal transition. The reverse process, mesenchymal–epithelial transition (MET), can similarly generate epithelial cells. Transitions between epithelial and mesenchymal states are also critical for the induction of pluripotent stem cells from somatic cells. This Review discusses the relatively less characterized process of MET, focusing on the genesis of apicobasal cell polarity and exploring the roles of MET in development and reprogramming.
This Review discusses the mesenchymal–epithelial transition and its roles in development, cellular fate conversions and somatic cell reprogramming.
Publisher
Nature Publishing Group UK,Nature Publishing Group
Subject
/ 13/100
/ 13/51
/ 13/95
/ 14/19
/ Animals
/ Biology
/ Biomedical and Life Sciences
/ Cell Differentiation - physiology
/ Cellular Reprogramming - physiology
/ Cellular signal transduction
/ Embryo, Mammalian - cytology
/ Embryo, Mammalian - embryology
/ Embryos
/ Epithelial Cells - physiology
/ Epithelial-Mesenchymal Transition - physiology
/ Health
/ Humans
/ Kinases
/ Mammals
/ Medicine
/ Mesenchymal Stem Cells - cytology
/ Mesenchymal Stem Cells - physiology
/ Physics
/ Polarity
/ Proteins
