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Biosynthesis and secretion of the microbial sulfated peptide RaxX and binding to the rice XA21 immune receptor
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Biosynthesis and secretion of the microbial sulfated peptide RaxX and binding to the rice XA21 immune receptor
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Journal Article
Biosynthesis and secretion of the microbial sulfated peptide RaxX and binding to the rice XA21 immune receptor
2019
Overview
The rice immune receptor XA21 is activated by the sulfated microbial peptide required for activation of XA21-mediated immunity X (RaxX) produced by Xanthomonas oryzae pv. oryzae (Xoo). Mutational studies and targeted proteomics revealed that the RaxX precursor peptide (proRaxX) is processed and secreted by the protease/transporter RaxB, the function of which can be partially fulfilled by a noncognate peptidase-containing transporter component B (PctB). proRaxX is cleaved at a Gly–Gly motif, yielding a mature peptide that retains the necessary elements for RaxX function as an immunogen and host peptide hormone mimic. These results indicate that RaxX is a prokaryotic member of a previously unclassified and understudied group of eukaryotic tyrosine sulfated ribosomally synthesized, posttranslationally modified peptides (RiPPs). We further demonstrate that sulfated RaxX directly binds XA21 with high affinity. This work reveals a complete, previously uncharacterized biological process: bacterial RiPP biosynthesis, secretion, binding to a eukaryotic receptor, and triggering of a robust host immune response.
Publisher
National Academy of Sciences,Proceedings of the National Academy of Sciences
Subject
ATP-Binding Cassette Transporters - chemistry
/ ATP-Binding Cassette Transporters - genetics
/ ATP-Binding Cassette Transporters - metabolism
/ Bacterial Proteins - chemistry
/ Bacterial Proteins - genetics
/ Bacterial Proteins - metabolism
/ Host-Pathogen Interactions - genetics
/ Host-Pathogen Interactions - immunology
/ Immunity
/ Metabolic Networks and Pathways - genetics
/ Peptide Hydrolases - chemistry
/ Peptide Hydrolases - genetics
/ Peptide Hydrolases - metabolism
/ Peptides
/ Protein-Serine-Threonine Kinases - chemistry
/ Protein-Serine-Threonine Kinases - immunology
/ Protein-Serine-Threonine Kinases - metabolism
/ Tyrosine
