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Immunogenicity and safety of two live-attenuated tetravalent dengue vaccine formulations in healthy Australian adults
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Immunogenicity and safety of two live-attenuated tetravalent dengue vaccine formulations in healthy Australian adults
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Journal Article
Immunogenicity and safety of two live-attenuated tetravalent dengue vaccine formulations in healthy Australian adults
2006
Overview
We conducted a Phase 1b study to evaluate the immunogenicity and safety of two live attenuated tetravalent dengue vaccines in healthy adult volunteers. After one injection, all subjects reported systemic reactions consistent with a mild dengue-like syndrome. Seven volunteers developed dengue 3 viraemia after vaccination. All subjects developed a neutralizing antibody response against serotype 3 with partial response against other serotypes. The trial was stopped early (after 10 subjects enrolled) due to formulation issues, which were related to the dengue 3 vaccine component. Managing viral interference and balancing attenuation to produce acceptable tetravalent immunogenicity with minimal reactogenicity may be a recurring problem for future multivalent live vaccines.
Publisher
Elsevier Ltd,Elsevier,Elsevier Limited
Subject
/ Biological and medical sciences
/ Dengue
/ Dengue - prevention & control
/ Fundamental and applied biological sciences. Psychology
/ Humans
/ Male
/ Vaccine
/ Vaccines
/ Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects)
/ Vaccines, Attenuated - administration & dosage
/ Vaccines, Attenuated - adverse effects
/ Vaccines, Attenuated - immunology
/ Viral Vaccines - administration & dosage
/ Viral Vaccines - adverse effects
/ Viremia
