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Frailty and sarcopenia - newly emerging and high impact complications of diabetes
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Frailty and sarcopenia - newly emerging and high impact complications of diabetes
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Journal Article
Frailty and sarcopenia - newly emerging and high impact complications of diabetes
2017
Overview
Diabetes increases the risk of physical dysfunction and disability. Diabetes-related complications and coexisting morbidities partially explain the deterioration in physical function. The decline in muscle mass, strength and function associated with diabetes leads to sarcopenia, frailty and eventually disability. Frailty acts as a mediator in the pathogenesis of disability in older people with diabetes and its measurement in routine daily practice is recommended. Frailty is a dynamic process which progresses from a robust condition to a pre-frail stage then frailty and eventually disability. Therefore, a multimodal intervention which includes adequate nutrition, exercise training, good glycaemic control and the use of appropriate hypoglycemic medications may help delay or prevent the progression to disability.
•This review addresses two key emerging complications in diabetes – frailty and sarcopenia. We know that diabetes increases the risk of physical dysfunction and disability but up to now, many have considered these outcomes due to the combined effects of micro- and macro-vascular complications. It is now becoming increasingly clear that such traditional diabetes-related complications and coexisting morbidities only partially explain the deterioration in physical function, and that frailty and underlying sarcopenia may be important in this decline in performance.•We provide an up to date and innovative approach to examining these issues and provide practical clinical guidance on assessment and management of these complications in a setting of diabetes in older adults.
Publisher
Elsevier Inc,Elsevier Limited
