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Imaging Biomaterial–Tissue Interactions
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Journal Article
Imaging Biomaterial–Tissue Interactions
2018
Overview
Modern biomedical imaging has revolutionized life science by providing anatomical, functional, and molecular information of biological species with high spatial resolution, deep penetration, enhanced temporal responsiveness, and improved chemical specificity. In recent years, these imaging techniques have been increasingly tailored for characterizing biomaterials and probing their interactions with biological tissues. This in turn has spurred substantial advances in engineering material properties to accommodate different imaging modalities that was previously unattainable. Here, we review advances in engineering both imaging modalities and material properties with improved contrast, providing a timely practical guide to better assess biomaterial–tissue interactions both in vitro and in vivo.
Interrogating biomaterial–tissue interactions with minimal invasiveness and high fidelity through imaging analyses is desired.
Various imaging modalities that are based on individually unique contrast mechanisms can be used to characterize biomaterial–tissue interactions in different manners.
Contrast mechanisms are constantly undergoing revolution and enable improved visualization of biomaterial–tissue interactions with relevant imaging modalities.
Unconventional toolkits have also been developed to promote the ability to image biological tissues and possibly biomaterials.
The development of multimodality imaging platforms and multiplexed contrast mechanisms in combination with new toolkits will allow for multiscale characterization of biomaterial–tissue interactions in high capacity.
Publisher
Elsevier Ltd,Elsevier Limited
