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Transduction of mechanical and cytoskeletal cues by YAP and TAZ
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Journal Article
Transduction of mechanical and cytoskeletal cues by YAP and TAZ
2012
Overview
Forces transmitted through cell–cell and cell–extracellular matrix adhesions control cell fate decisions. But how are mechanical cues translated into gene expression programmes? The transcriptional regulators YAP and TAZ have arisen as convergence points of mechanical and biochemical signals.
The physical and mechanical properties of the cellular microenvironment regulate cell shape and can strongly influence cell fate. How mechanical cues are sensed and transduced to regulate gene expression has long remained elusive. Recently, cues from the extracellular matrix, cell adhesion sites, cell shape and the actomyosin cytoskeleton were found to converge on the regulation of the downstream effectors of the Hippo pathway YAP (Yes-associated protein) and TAZ (transcriptional co-activator with PDZ-binding motif) in vertebrates and Yorkie in flies. This convergence may explain how mechanical signals can direct normal and pathological cell behaviour.
Publisher
Nature Publishing Group UK,Nature Publishing Group
Subject
/ 86
/ Adaptor Proteins, Signal Transducing - metabolism
/ Adhesion
/ Animals
/ Biomedical and Life Sciences
/ Cellular signal transduction
/ Extracellular Matrix - metabolism
/ Humans
/ Insects
/ Intracellular Signaling Peptides and Proteins - metabolism
/ Kinases
/ Mechanotransduction, Cellular
/ Mesenchymal Stem Cells - metabolism
/ Nuclear Proteins - metabolism
/ Phosphoproteins - metabolism
/ Proteins
