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Elmo1 function, linked to Rac1 activity, regulates peripheral neuronal numbers and myelination in zebrafish
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Elmo1 function, linked to Rac1 activity, regulates peripheral neuronal numbers and myelination in zebrafish
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Journal Article
Elmo1 function, linked to Rac1 activity, regulates peripheral neuronal numbers and myelination in zebrafish
2020
Overview
Peripheral nervous system development involves a tight coordination of neuronal birth and death and a substantial remodelling of the myelinating glia cytoskeleton to achieve myelin wrapping of its projecting axons. However, how these processes are coordinated through time is still not understood. We have identified engulfment and cell motility 1, Elmo1, as a novel component that regulates (i) neuronal numbers within the Posterior Lateral Line ganglion and (ii) radial sorting of axons by Schwann cells (SC) and myelination in the PLL system in zebrafish. Our results show that neuronal and myelination defects observed in
elmo1
mutant are rescued through small GTPase Rac1 activation. Inhibiting macrophage development leads to a decrease in neuronal numbers, while peripheral myelination is intact. However,
elmo1
mutants do not show defective macrophage activity, suggesting a role for Elmo1 in PLLg neuronal development and SC myelination independent of macrophages. Forcing early Elmo1 and Rac1 expression specifically within SCs rescues
elmo1
−/−
myelination defects, highlighting an autonomous role for Elmo1 and Rac1 in radial sorting of axons by SCs and myelination. This uncovers a previously unknown function of Elmo1 that regulates fundamental aspects of PNS development.
Publisher
Springer International Publishing,Springer Nature B.V,Springer Verlag
Subject
Adaptor Proteins, Signal Transducing - metabolism
/ Animals
/ Axons
/ Biomedical and Life Sciences
/ death
/ Defects
/ ganglia
/ Motility
/ Mutants
/ Myelin
/ Original
/ Peripheral Nerves - growth & development
/ Peripheral Nerves - ultrastructure
/ Proteins
/ rac1 GTP-Binding Protein - metabolism
/ Schwann Cells - ultrastructure
