Asset Details
Do you wish to reserve the book?
Global variation in CYP2C8–CYP2C9 functional haplotypes
Hey, we have placed the reservation for you!
By the way, why not check out events that you can attend while you pick your title.
Oops! Something went wrong.
Looks like we were not able to place the reservation. Kindly try again later.
Are you sure you want to remove the book from the shelf?
Global variation in CYP2C8–CYP2C9 functional haplotypes
Do you wish to request the book?
Global variation in CYP2C8–CYP2C9 functional haplotypes
Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy
We have requested the book for you!
Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.
Oops! Something went wrong.
Looks like we were not able to place your request. Kindly try again later.
Journal Article
Global variation in CYP2C8–CYP2C9 functional haplotypes
2009
Overview
We have studied the global frequency distributions of 10 single nucleotide polymorphisms (SNPs) across 132 kb of
CYP2C8
and
CYP2C9
in ∼2500 individuals representing 45 populations. Five of the SNPs were in noncoding sequences; the other five involved the more common missense variants (four in
CYP2C8
, one in
CYP2C9
) that change amino acids in the gene products. One haplotype containing two
CYP2C8
coding variants and one
CYP2C9
coding variant reaches an average frequency of 10% in Europe; a set of haplotypes with a different
CYP2C8
coding variant reaches 17% in Africa. In both cases these haplotypes are found in other regions of the world at <1%. This considerable geographic variation in haplotype frequencies impacts the interpretation of
CYP2C8/CYP2C9
association studies, and has pharmacogenomic implications for drug interactions.
Publisher
Nature Publishing Group UK,Nature Publishing Group
