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At the heart of mitochondrial quality control: many roads to the top
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Journal Article
At the heart of mitochondrial quality control: many roads to the top
2021
Overview
Mitochondrial quality control depends upon selective elimination of damaged mitochondria, replacement by mitochondrial biogenesis, redistribution of mitochondrial components across the network by fusion, and segregation of damaged mitochondria by fission prior to mitophagy. In this review, we focus on mitochondrial dynamics (fusion/fission), mitophagy, and other mechanisms supporting mitochondrial quality control including maintenance of mtDNA and the mitochondrial unfolded protein response, particularly in the context of the heart.
Publisher
Springer Nature B.V
Subject
