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Wnt/beta-catenin pathway: modulating anticancer immune response
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Wnt/beta-catenin pathway: modulating anticancer immune response
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Journal Article
Wnt/beta-catenin pathway: modulating anticancer immune response
2017
Overview
Wnt/β-catenin signaling, a highly conserved pathway through evolution, regulates key cellular functions including proliferation, differentiation, migration, genetic stability, apoptosis, and stem cell renewal. The Wnt pathway mediates biological processes by a canonical or noncanonical pathway, depending on the involvement of β-catenin in signal transduction. β-catenin is a core component of the cadherin protein complex, whose stabilization is essential for the activation of Wnt/β-catenin signaling. As multiple aberrations in this pathway occur in numerous cancers, WNT-directed therapy represents an area of significant developmental therapeutics focus. The recently described role of Wnt/β-catenin pathway in regulating immune cell infiltration of the tumor microenvironment renewed the interest, given its potential impact on responses to immunotherapy treatments. This article summarizes the role of Wnt/β-catenin pathway in cancer and ongoing therapeutic strategies involving this pathway.
Publisher
BioMed Central,BMC
Subject
Acyltransferases - antagonists & inhibitors
/ Antineoplastic Agents - pharmacology
/ Antineoplastic Agents - therapeutic use
/ Antineoplastic Combined Chemotherapy Protocols - therapeutic use
/ beta Catenin - antagonists & inhibitors
/ Cell Communication - drug effects
/ Humans
/ Medicine
/ Membrane Proteins - antagonists & inhibitors
/ Neoplasm Proteins - antagonists & inhibitors
/ Neoplasm Proteins - physiology
/ Observational Studies as Topic
/ Oncology
/ Review
/ T-Lymphocyte Subsets - immunology
/ Tankyrases - antagonists & inhibitors
/ Wnt
/ Wnt Proteins - antagonists & inhibitors
