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Reliability of efficacy in men with erectile dysfunction treated with tadalafil once daily after initial success
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Reliability of efficacy in men with erectile dysfunction treated with tadalafil once daily after initial success
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Journal Article
Reliability of efficacy in men with erectile dysfunction treated with tadalafil once daily after initial success
2010
Overview
The reliability of response to treatment is an important component of erectile dysfunction (ED) treatment. This study examined the reliability of tadalafil once daily (that is, successful attempts/total attempts) following initial successful intercourse. Data pooled from two randomized, double-blind, placebo-controlled trials of men with ED who received tadalafil 2.5 mg (
N
=96), tadalafil 5 mg (
N
=206) or placebo (
N
=148) once daily were analyzed to determine the first-attempt success rate and subsequent reliability of response. The first-attempt success rate (Sexual Encounter Profile question 3 (SEP3)) was significantly higher among men taking tadalafil 2.5 mg (45.7%) and 5 mg (55.2%) compared to placebo (28.5%;
P
<0.05 and
P
<0.001, respectively). Furthermore, following initial success, men taking tadalafil 5 mg had a significantly greater proportion of successful intercourse (SEP3) on subsequent attempts (85.9%,
P
<0.001) compared to men taking placebo (70.2%). Overall, men with ED taking tadalafil once daily experienced a high rate of reliability of efficacy.
Publisher
Nature Publishing Group UK,Nature Publishing Group
Subject
/ Biological and medical sciences
/ Carbolines - administration & dosage
/ Carbolines - therapeutic use
/ Coitus
/ Cyclic Nucleotide Phosphodiesterases, Type 5 - administration & dosage
/ Erectile Dysfunction - drug therapy
/ Gynecology. Andrology. Obstetrics
/ Humans
/ Male
/ Medicine
/ Men
/ Phosphodiesterase 5 Inhibitors
/ Phosphodiesterase Inhibitors - administration & dosage
/ Phosphodiesterase Inhibitors - therapeutic use
/ rology
/ Success
/ Urology
