Journal Article

Event-related variability is modulated by task and development

Naik, Shruti, Dubois, Jessica, Dehaene-Lambertz, Ghislaine, Adibpour, Parvaneh, Battaglia, Demian

2023

Overview

•Stimulus driven modulations of neural variability are richly structured in time.•Event Related Variability (ERV) patterns are already structured in early infancy.•ERV patterns depend on task and age (in 2-6 month old infants and adults).•ERV patterns are not fully explained by induced phase reset or microstate switching.•Within-trial variability may reflect sampling of a structured dynamical landscape. In carefully designed experimental paradigms, cognitive scientists interpret the mean event-related potentials (ERP) in terms of cognitive operations. However, the huge signal variability from one trial to the next, questions the representability of such mean events. We explored here whether this variability is an unwanted noise, or an informative part of the neural response. We took advantage of the rapid changes in the visual system during human infancy and analyzed the variability of visual responses to central and lateralized faces in 2-to 6-month-old infants compared to adults using high-density electroencephalography (EEG). We observed that neural trajectories of individual trials always remain very far from ERP components, only moderately bending their direction with a substantial temporal jitter across trials. However, single trial trajectories displayed characteristic patterns of acceleration and deceleration when approaching ERP components, as if they were under the active influence of steering forces causing transient attraction and stabilization. These dynamic events could only partly be accounted for by induced microstate transitions or phase reset phenomena. Importantly, these structured modulations of response variability, both between and within trials, had a rich sequential organization, which in infants, was modulated by the task difficulty and age. Our approaches to characterize Event Related Variability (ERV) expand on classic ERP analyses and provide the first evidence for the functional role of ongoing neural variability in human infants.

• Publisher: Elsevier Inc,Elsevier Limited,Elsevier
• Subject: Babies / Brain / Cognition & reasoning / Cognitive ability / Dynamical systems / Early infancy / EEG / EEG dynamics / Event-related potentials / Infants / Neural variability / Reproducibility / Spontaneous activity / Topography / Vision / Visual system