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The development and maintenance of resident macrophages
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The development and maintenance of resident macrophages
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Journal Article
The development and maintenance of resident macrophages
2016
Overview
Gomez Perdiguero and Geissmann discuss the origin of tissue macrophages as a layered system composed of resident macrophages originating mostly from yolk-sac progenitor cells and transitory myeloid cells that originate and renew from bone marrow hematopoietic stem cells.
The molecular and cellular mechanisms that underlie the many roles of macrophages in health and disease states
in vivo
remain poorly understood. The purpose of this Review is to present and discuss current knowledge on the developmental biology of macrophages, as it underlies the concept of a layered myeloid system composed of 'resident' macrophages that originate mainly from progenitor cells generated in the yolk sac and of 'passenger' or 'transitory' myeloid cells that originate and renew from bone marrow hematopoietic stem cells, and to provide a framework for investigating the functions of macrophages
in vivo
.
