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Genomically Recoded Organisms Expand Biological Functions

by Isaacs, Farren J. , Mosberg, Joshua A. , Kuznetsov, Gleb , Lajoie, Marc J. , Jacobson, Joseph M. , Carr, Peter A. , Aerni, Hans-Rudolf , Goodman, Daniel B. , Schultz, Peter G. , Rohland, Nadin , Wang, Harris H. , Mercer, Jaron A. , Haimovich, Adrian D. , Church, George M. , Rinehart, Jesse , Rovner, Alexis J.

in Amino Acid Substitution - genetics / Amino acids / Amino Acids - genetics / Bacteriology / Bacteriophage T7 - physiology / bacteriophages / Codon, Terminator - genetics / E coli / energy / engineers / Escherichia coli / Escherichia coli - genetics / Escherichia coli - virology / Escherichia coli Proteins - genetics / essential genes / genetic code / Genetic Engineering / Genome, Bacterial / Genomics / medicine / Microbiology / Organisms, Genetically Modified - genetics / Organisms, Genetically Modified - virology / Peptide Chain Termination, Translational - genetics / Peptide Termination Factors - genetics / Proteins / stop codon / Translation / translation (genetics)

2013

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2013

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Genomically Recoded Organisms Expand Biological Functions

2013

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Journal Article

Genomically Recoded Organisms Expand Biological Functions

Isaacs, Farren J.,

Mosberg, Joshua A.,

Kuznetsov, Gleb,

Lajoie, Marc J.,

Jacobson, Joseph M.,

Carr, Peter A.,

Aerni, Hans-Rudolf,

Goodman, Daniel B.,

Schultz, Peter G.,

Rohland, Nadin,

Wang, Harris H.,

Mercer, Jaron A.,

Haimovich, Adrian D.,

Church, George M.,

Rinehart, Jesse,

Rovner, Alexis J.

2013

Overview

We describe the construction and characterization of a genomically recoded organism (GRO). We replaced all known UAG stop codons in Escherichia coli MG1655 with synonymous UAA codons, which permitted the deletion of release factor 1 and reassignment of UAG translation function. This GRO exhibited improved properties for incorporation of nonstandard amino acids that expand the chemical diversity of proteins in vivo. The GRO also exhibited increased resistance to T7 bacteriophage, demonstrating that new genetic codes could enable increased viral resistance.

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Publisher

American Association for the Advancement of Science,The American Association for the Advancement of Science

Subject

Amino Acid Substitution - genetics

/ Amino acids

/ Amino Acids - genetics

/ Bacteriology

/ Bacteriophage T7 - physiology

/ bacteriophages

/ Codon, Terminator - genetics