Journal Article

Structural-functional brain network coupling predicts human cognitive ability

Sporns, Olaf, Thiele, Jonas A., Faskowitz, Joshua, Seguin, Caio, Hilger, Kirsten, Popp, Johanna L.

2024

Overview

•Brain structure-function coupling captured by network communication models.•Stronger structure-function coupling is linked to higher general cognitive ability.•Region-specific coupling strategies predict individual cognitive ability scores.•Prediction model generalizes across independent samples.•Efficient cognitive processing may depend on region-specific coupling strategies. Individual differences in general cognitive ability (GCA) have a biological basis within the structure and function of the human brain. Network neuroscience investigations revealed neural correlates of GCA in structural as well as in functional brain networks. However, whether the relationship between structural and functional networks, the structural-functional brain network coupling (SC-FC coupling), is related to individual differences in GCA remains an open question. We used data from 1030 adults of the Human Connectome Project, derived structural connectivity from diffusion weighted imaging, functional connectivity from resting-state fMRI, and assessed GCA as a latent g-factor from 12 cognitive tasks. Two similarity measures and six communication measures were used to model possible functional interactions arising from structural brain networks. SC-FC coupling was estimated as the degree to which these measures align with the actual functional connectivity, providing insights into different neural communication strategies. At the whole-brain level, higher GCA was associated with higher SC-FC coupling, but only when considering path transitivity as neural communication strategy. Taking region-specific variations in the SC-FC coupling strategy into account and differentiating between positive and negative associations with GCA, allows for prediction of individual cognitive ability scores in a cross-validated prediction framework (correlation between predicted and observed scores: r = 0.25, p < .001). The same model also predicts GCA scores in a completely independent sample (N = 567, r = 0.19, p < .001). Our results propose structural-functional brain network coupling as a neurobiological correlate of GCA and suggest brain region-specific coupling strategies as neural basis of efficient information processing predictive of cognitive ability.

• Publisher: Elsevier Inc,Elsevier Limited,Elsevier
• Subject: Brain mapping / Brain research / Cognition & reasoning / Cognitive ability / Communication / Functional connectivity / Functional magnetic resonance imaging / General cognitive ability / Information processing / Intelligence / Network communication models / Neural networks / Neuroimaging / Neurosciences / Similarity measures / Structural connectivity / Structure-function coupling / Structure-function relationships