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Regulation of brain endothelial cell physiology by the TAM receptor tyrosine kinase Mer
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Regulation of brain endothelial cell physiology by the TAM receptor tyrosine kinase Mer
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Journal Article
Regulation of brain endothelial cell physiology by the TAM receptor tyrosine kinase Mer
2023
Overview
The receptor tyrosine kinase Mer (gene name
Mertk
) acts in vascular endothelial cells (ECs) to tighten the blood-brain barrier (BBB) subsequent to viral infection, but how this is achieved is poorly understood. We find that Mer controls the expression and activity of a large cohort of BBB regulators, along with endothelial nitric oxide synthase. It also controls, via an Akt-Foxo1 pathway, the expression of multiple angiogenic genes. Correspondingly, EC-specific
Mertk
gene inactivation resulted in perturbed vascular sprouting and a compromised BBB after induced photothrombotic stroke. Unexpectedly, stroke lesions in the brain were also reduced in the absence of EC Mer, which was linked to reduced plasma expression of fibrinogen, prothrombin, and other effectors of blood coagulation. Together, these results demonstrate that Mer is a central regulator of angiogenesis, BBB integrity, and blood coagulation in the mature vasculature. They may also account for disease severity following infection with the coronavirus SARS-CoV-2.
Transcriptomics and proteomics studies show that the endothelial cell-specific genetic inactivation of Mer leads to pleiotropic deficits in angiogenesis, blood brain barrier formation, and blood coagulation.
Publisher
Nature Publishing Group UK,Nature Publishing Group,Nature Portfolio
Subject
