Journal Article

Assessment of vibration modulated regional cerebral blood flow with MRI

Deng, Linhong, He, Zhao, Feng, Xi-Qiao, Kong, Linghan, Yang, Guang-Zhong, Chen, Yu, Qiu, Suhao, Feng, Yuan, Zhang, Ru-Yuan, Li, Yao, He, Qiang, Huang, Peiyu, Yan, Fuhua

2023

Overview

•Physiological changes in the brain under different vibration frequencies were measured using a custom-built vibration instrument.•Cerebral blood flow was modulated with vibration and decreased with increased frequency.•The regions with a significant cerebral blood flow decrease coincided with the default mode network. Human brain experiences vibration of certain magnitude and frequency during various physical activities such as vehicle transportation and machine operation, which may cause traumatic brain injury or other brain diseases. However, the mechanisms of brain pathogenesis due to vibration are not fully elucidated due to the lack of techniques to study brain functions while applying vibration to the brain at a specific magnitude and frequency. Here, this study reported a custom-built head-worn electromagnetic actuator that applied vibration to the brain in vivo at an accurate frequency inside a magnetic resonance imaging scanner while cerebral blood flow (CBF) was acquired. Using this technique, CBF values from 45 healthy volunteers were quantitatively measured immediately following vibration at 20, 30, 40 Hz, respectively. Results showed increasingly reduced CBF with increasing frequency at multiple regions of the brain, while the size of the regions expanded. Importantly, the vibration-induced CBF reduction regions largely fell inside the brain's default mode network (DMN), with about 58 or 46% overlap at 30 or 40 Hz, respectively. These findings demonstrate that vibration as a mechanical stimulus can change strain conditions, which may induce CBF reduction in the brain with regional differences in a frequency-dependent manner. Furthermore, the overlap between vibration-induced CBF reduction regions and DMN suggested a potential relationship between external mechanical stimuli and cognitive functions.

• Publisher: Elsevier Inc,Elsevier Limited,Elsevier
• Subject: Blood flow / Brain / Cerebral blood flow / Cerebrovascular Circulation - physiology / Cognition / Cognitive ability / Default mode network / Frequency dependence / Humans / Magnetic Resonance Imaging / Mechanical stimuli / Neuroimaging / Physiology / Shear strain / Traumatic brain injury / Vibration