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Duplication of the MYB oncogene in T cell acute lymphoblastic leukemia

by Van Vlierberghe, Pieter , De Keersmaecker, Kim , Froyen, Guy , Wlodarska, Iwona , Lambert, Frederic , Pieters, Rob , Lahortiga, Idoya , Bauters, Marijke , Graux, Carlos , Odero, Maria D , Beverloo, H Berna , Cools, Jan , Cauwelier, Barbara , Mentens, Nicole , Vandenberghe, Peter , Speleman, Frank , Meijerink, Jules P P , Marynen, Peter

in Acute lymphocytic leukemia / Agriculture / Animal Genetics and Genomics / Biological and medical sciences / Biomedical and Life Sciences / Biomedicine / brief-communication / Cancer Research / Cell differentiation / Cell Differentiation - genetics / Cell Differentiation - immunology / Cell Line, Tumor / Cell physiology / Cell transformation and carcinogenesis. Action of oncogenes and antioncogenes / Chromosomes, Artificial - genetics / Diagnosis / Flow Cytometry / Fundamental and applied biological sciences. Psychology / Gene Dosage / Gene Duplication / Gene expression / Gene Expression Regulation, Neoplastic - genetics / Gene Function / Genes, myb - genetics / Genetic markers / Genetic Testing / Genetics / Genetics & genetic processes / Genetics of eukaryotes. Biological and molecular evolution / Génétique & processus génétiques / Health aspects / Hematologic and hematopoietic diseases / Human Genetics / Humans / In Situ Hybridization, Fluorescence / Karyotyping / Leukemia / Leukemia-Lymphoma, Adult T-Cell - genetics / Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis / Life sciences / Medical sciences / Molecular and cellular biology / Mutation - genetics / Nucleic Acid Hybridization - genetics / Physiological aspects / Risk factors / RNA, Small Interfering - genetics / Sciences du vivant / Statistics, Nonparametric / T cells / T-Lymphocytes - pathology

2007

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Duplication of the MYB oncogene in T cell acute lymphoblastic leukemia

2007

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2007

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Journal Article

Duplication of the MYB oncogene in T cell acute lymphoblastic leukemia

Van Vlierberghe, Pieter,

De Keersmaecker, Kim,

Froyen, Guy,

Wlodarska, Iwona,

Lambert, Frederic,

Pieters, Rob,

Lahortiga, Idoya,

Bauters, Marijke,

Graux, Carlos,

Odero, Maria D,

Beverloo, H Berna,

Cools, Jan,

Cauwelier, Barbara,

Mentens, Nicole,

Vandenberghe, Peter,

Speleman, Frank,

Meijerink, Jules P P,

Marynen, Peter

2007

Overview

We identified a duplication of the MYB oncogene in 8.4% of individuals with T cell acute lymphoblastic leukemia (T-ALL) and in five T-ALL cell lines. The duplication is associated with a threefold increase in MYB expression, and knockdown of MYB expression initiates T cell differentiation. Our results identify duplication of MYB as an oncogenic event and suggest that MYB could be a therapeutic target in human T-ALL.

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Publisher

Nature Publishing Group US,Nature Publishing Group,Nature

Subject

Acute lymphocytic leukemia

/ Agriculture

/ Animal Genetics and Genomics

/ Biological and medical sciences

/ Biomedical and Life Sciences

/ Biomedicine

/ brief-communication