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Stroma-normalised vessel density predicts benefit from adjuvant fluorouracil-based chemotherapy in patients with stage II/III colon cancer
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Stroma-normalised vessel density predicts benefit from adjuvant fluorouracil-based chemotherapy in patients with stage II/III colon cancer
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Stroma-normalised vessel density predicts benefit from adjuvant fluorouracil-based chemotherapy in patients with stage II/III colon cancer
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Journal Article
Stroma-normalised vessel density predicts benefit from adjuvant fluorouracil-based chemotherapy in patients with stage II/III colon cancer
2019
Overview
Background
Identification of biomarkers associated with benefit of adjuvant chemotherapy in stage II/III colon cancer is an important task.
Methods
Vessel density (VD) and tumour stroma were analysed in a randomised-trial-derived discovery cohort (
n
= 312) and in a stage II/III group of a population-based validation cohort (
n
= 85). VD was scored separately in the tumour centre, invasive margin and peritumoral stroma compartments and quantitated as VD/total analysed tissue area or VD/stroma area.
Results
High stroma-normalised VD in the invasive margin was associated with significantly longer time to recurrence and overall survival (OS) (
p
= 0.002 and
p
= 0.006, respectively) in adjuvant-treated patients of the discovery cohort, but not in surgery-only patients. Stroma-normalised VD in the invasive margin and treatment effect were significantly associated according to a formal interaction test (
p
= 0.009). Similarly, in the validation cohort, high stroma-normalised VD was associated with OS in adjuvant-treated patients, although statistical significance was not reached (
p
= 0.051).
Conclusion
Through the use of novel digitally scored vessel-density-related metrics, this exploratory study identifies stroma-normalised VD in the invasive margin as a candidate marker for benefit of adjuvant 5-FU-based chemotherapy in stage II/III colon cancer. The findings, indicating particular importance of vessels in the invasive margin, also suggest biological mechanisms for further exploration.
Publisher
Nature Publishing Group UK,Nature Publishing Group
Subject
/ Antineoplastic Combined Chemotherapy Protocols - therapeutic use
/ Biomedical and Life Sciences
/ Colonic Neoplasms - blood supply
/ Colonic Neoplasms - drug therapy
/ Colonic Neoplasms - mortality
/ Colonic Neoplasms - pathology
/ Fluorouracil - administration & dosage
/ Humans
/ Oncology
/ Patients
/ Stroma
/ Surgery
/ Tumors
