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Interplay Between SIRT-3, Metabolism and Its Tumor Suppressor Role in Hepatocellular Carcinoma
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Interplay Between SIRT-3, Metabolism and Its Tumor Suppressor Role in Hepatocellular Carcinoma
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Journal Article
Interplay Between SIRT-3, Metabolism and Its Tumor Suppressor Role in Hepatocellular Carcinoma
2017
Overview
Sirtuins (SIRT), first described as nicotinamide adenine dinucleotide (NAD
+
)-dependent type III histone deacetylases, are produced by cells to support in the defense against chronic stress conditions such as metabolic syndromes, neurodegeneration, and cancer. SIRT-3 is one of the most studied members of the mitochondrial sirtuins family. In particular, its involvement in metabolic diseases and its dual role in cancer have been described. In the present review, based on the evidence of SIRT-3 involvement in metabolic dysfunctions, we aimed to provide an insight into the multifaceted role of SIRT-3 in many solid and hematological tumors with a particular focus on hepatocellular carcinoma (HCC). SIRT-3 regulatory effect and involvement in metabolism dysfunctions may have strong implications in HCC development and treatment. Research literature widely reports the relationship between metabolic disorders and HCC development. This evidence suggests a putative bridge role of SIRT-3 between metabolic diseases and HCC. However, further studies are necessary to demonstrate such interconnection.
Publisher
Springer Science and Business Media LLC,Springer US,Springer,Springer Nature B.V
Subject
/ Cancer
/ Carcinoma, Hepatocellular - etiology
/ Carcinoma, Hepatocellular - metabolism
/ Hepatocellular carcinoma; Metabolism; SIRT-3; Tumor suppressor
/ Hepatocellular carcinoma; Metabolism; SIRT-3; Tumor suppressor; Physiology; Gastroenterology
/ hepatocellular carcinoma; SIRT-3; tumor suppressor
/ Hepatoma
/ Humans
/ Liver Neoplasms - metabolism
/ Medicine
/ Metabolic Diseases - complications
/ Oncology
/ Review
/ SIRT-3
