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CD8 + T Cells in Hodgkin’s Disease Tumor Tissue Are a Polyclonal Population with Limited Clonal Expansion but Little Evidence of Selection by Antigen
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CD8 + T Cells in Hodgkin’s Disease Tumor Tissue Are a Polyclonal Population with Limited Clonal Expansion but Little Evidence of Selection by Antigen
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Journal Article
CD8 + T Cells in Hodgkin’s Disease Tumor Tissue Are a Polyclonal Population with Limited Clonal Expansion but Little Evidence of Selection by Antigen
2000
Overview
A minor component (about 25%) of lymphocytes in Hodgkin’s disease (HD) are CD8
+ T cells. It is unclear whether the presence of these cells reflects an antitumor cytotoxic response. The goal of the present study was to investigate clonal composition and the T cell receptor (TCR) β repertoire of the CD8
+ T cell population in HD. Single CD8
+ cells were micromanipulated from frozen tissue sections of lymph nodes affected by primary HD and subjected to single target amplification of TCRβ gene rearrangements. Sequence analysis of the V region genes revealed the presence of expanded CD8
+ T cell clones in all three cases analyzed. Most of these clonal expansions accounted for less than 10% of the CD8
+ T cell population. In one case, 30% of the CD8
+ T cells belonged to one or two clones. Comparison of V region sequences, however, did not provide evidence that the micromanipulated CD8
+ cells were sampled from a population that was selected for particular antigen specificities. No obvious biases in TCR Vβ and Jβ gene segment usage or CDR3 length distribution were found. Similarities of CDR3 amino acid sequences as found in selected CDR3 structures were rare. These results suggest that, like CD4
+ T cells, CD8
+ T cells may also be recruited into the tumor tissue in an antigen-nonspecific manner.
Publisher
Elsevier Inc,ASIP,American Society for Investigative Pathology
Subject
Biological and medical sciences
/ CD8-Positive T-Lymphocytes - cytology
/ CD8-Positive T-Lymphocytes - immunology
/ CD8-Positive T-Lymphocytes - metabolism
/ Gene Rearrangement, beta-Chain T-Cell Antigen Receptor - genetics
/ Genes, T-Cell Receptor beta - genetics
/ Hematologic and hematopoietic diseases
/ Hodgkin Disease - immunology
/ Humans
/ Immunoglobulin Variable Region - genetics
/ Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis
/ Regular
