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培美曲塞单药或联合铂类三线及以上治疗晚期非鳞型非小细胞肺癌的临床观察
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培美曲塞单药或联合铂类三线及以上治疗晚期非鳞型非小细胞肺癌的临床观察
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培美曲塞单药或联合铂类三线及以上治疗晚期非鳞型非小细胞肺癌的临床观察
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Journal Article
培美曲塞单药或联合铂类三线及以上治疗晚期非鳞型非小细胞肺癌的临床观察
2012
Overview
背景与目的培美曲塞联合铂类或单药在晚期非小细胞肺癌一、二线治疗中的疗效已得到验证,但其在三线及以上治疗中的地位还不明确。本文旨在观察培美曲塞单药或联合铂类三线及以上治疗晚期非鳞型非小细胞肺癌的临床疗效及安全性。方法 46例多线治疗失败的晚期非鳞型非小细胞肺癌患者接受培美曲塞单药或联合铂类药物治疗。结果 46例晚期非鳞型非小细胞肺癌患者中部分缓解7例,疾病稳定20例,疾病进展19例,客观缓解率为15.2%,疾病控制率为58.7%,中位无疾病进展时间为3.0个月。分析显示培美曲塞联合卡铂及顺铂较培美曲塞单药治疗的疾病控制率明显增高（P=0.043）。常见的不良反应主要有恶心、呕吐及骨髓抑制。结论应用培美曲塞单药或联合铂类治疗多线治疗失败的晚期非鳞型非小细胞肺癌患者仍可使其临床获益,且毒副反应可耐受。
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