Journal Article

Mapping the human brain's cortical-subcortical functional network organization

Ji, Jie Lisa, Repovš, Grega, Kulkarni, Kaustubh, Cole, Michael W., Spronk, Marjolein, Anticevic, Alan

2019

Overview

Understanding complex systems such as the human brain requires characterization of the system's architecture across multiple levels of organization – from neurons, to local circuits, to brain regions, and ultimately large-scale brain networks. Here we focus on characterizing the human brain's large-scale network organization, as it provides an overall framework for the organization of all other levels. We developed a highly principled approach to identify cortical network communities at the level of functional systems, calibrating our community detection algorithm using extremely well-established sensory and motor systems as guides. Building on previous network partitions, we replicated and expanded upon well-known and recently-identified networks, including several higher-order cognitive networks such as a left-lateralized language network. We expanded these cortical networks to subcortex, revealing 358 highly-organized subcortical parcels that take part in forming whole-brain functional networks. Notably, the identified subcortical parcels are similar in number to a recent estimate of the number of cortical parcels (360). This whole-brain network atlas – released as an open resource for the neuroscience community – places all brain structures across both cortex and subcortex into a single large-scale functional framework, with the potential to facilitate a variety of studies investigating large-scale functional networks in health and disease. •Large-scale functional network map of the entire human brain.•Cortical networks based on multiband fMRI, recently-identified regions.•Subcortical extension of networks covering all subcortical structures.•Multiple quality assessments demonstrate robustness of functional networks.•Network atlas released as public resource, providing framework for future studies.

• Publisher: Elsevier Inc,Elsevier Limited
• Subject: Brain / Brain - anatomy & histology / Brain - physiology / Brain architecture / Brain connectivity / Brain mapping / Brain networks / Calibration / Cognitive ability / Connectome - methods / Data analysis / Functional morphology / Functional MRI / Humans / Image Processing, Computer-Assisted / Magnetic Resonance Imaging / Motor systems / Nerve Net - anatomy & histology / Nerve Net - physiology / Nervous system / Neurosciences / Resting-state functional connectivity / Somatosensory cortex / Studies / Taxonomy