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非小细胞肺癌组织miRNA-221表达及其与预后的关系研究
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非小细胞肺癌组织miRNA-221表达及其与预后的关系研究
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Journal Article
非小细胞肺癌组织miRNA-221表达及其与预后的关系研究
2014
Overview
背景与目的microRNAs是肿瘤的重要调控因子，其中miRNA-221的表达与多种肿瘤相关，本研究旨在探讨miRNA-221在非小细胞肺癌组织中的表达及其与预后的关系。方法分析江苏省肿瘤医院2005年11月．2007年1月期间行手术治疗的117例非小细胞肺癌患者的临床资料。采用实时定量逆转录聚合酶链反应检测上述病例肺癌标本中miRNA-221的水平；应用x^2。检验分析miRNA-221表达水平与各临床病理参数的关系；采用Kaplan-Meier方法分析miRNA-221表达与非小细胞肺癌生存期（overall survival，OS）之间的关系；采用Cox风险比例模型分析各个协变量的联合效应。以P〈0．05认为差异有统计学意义。结果miRNA-221的表达量与患者年龄相关，与患者性别（χ^2=0．070，P=0．791）、病理类型（χ^2=0．414,P=0．520）、p-TNM分期（χ^2=0．068，P=0．794）及吸烟史（χ^2=0．206,P=0．650）无明显关系；生存分析显示miRNA．221高表达组患者生存期显著低于低表达组（P〈0．001）。Cox风险比例模型分析显示miRNA-221表达可作为非小细胞肺癌患者预后不良的标志。结论miRNA-221的高表达提示非小细胞肺癌患者预后较差，是潜在的肺癌预后预测分子标志物。
