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吉非替尼治疗晚期非小细胞肺癌耐药后的进展模式分析
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吉非替尼治疗晚期非小细胞肺癌耐药后的进展模式分析
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Journal Article
吉非替尼治疗晚期非小细胞肺癌耐药后的进展模式分析
2013
Overview
背景与目的观察表皮生长因子受体酪氨酸激酶抑制剂吉非替尼（Iressa）治疗晚期非小细胞肺癌（non-small cell lung cancer, NSCLC）获益后出现耐药的临床表现和进程。方法回顾性分析了我院内科接受吉非替尼治疗的93例晚期NSCLC患者，有效或稳定超过6个月，腺癌94.6%，女性79.6%，不吸烟者80.6%。每2个月评估疗效，观察耐药出现的临床表现。结果本组93例，中位服药时间16个月（8个月-70个月），用药时间超过2年占21.5%（20/93），超过3年8.6%（8/93）。耐药出现时的临床表现主要为胸腔内进展，占80%（72/90），其中原发病灶及术后断端复发进展占38.9%（35/90），肺内转移占51.1%（46/90），胸膜转移占25.6%（23/90）；颅内进展30%（30/90）；腹腔内进展15.6%（14/90）。结论 EGFRTKI治疗耐药后的进展在临床上表现为多样化，治疗后的预后不同，因此，需要密切的临床随访以期早期发现、及时处理。
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