Asset Details
Do you wish to reserve the book?
Crystallin proteins and amyloid fibrils
Hey, we have placed the reservation for you!
By the way, why not check out events that you can attend while you pick your title.
Oops! Something went wrong.
Looks like we were not able to place the reservation. Kindly try again later.
Are you sure you want to remove the book from the shelf?
Crystallin proteins and amyloid fibrils
Do you wish to request the book?
Crystallin proteins and amyloid fibrils
Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy
We have requested the book for you!
Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.
Oops! Something went wrong.
Looks like we were not able to place your request. Kindly try again later.
Journal Article
Crystallin proteins and amyloid fibrils
2009
Overview
Improper protein folding (misfolding) can lead to the formation of disordered (amorphous) or ordered (amyloid fibril) aggregates. The major lens protein, α-crystallin, is a member of the small heat-shock protein (sHsp) family of intracellular molecular chaperone proteins that prevent protein aggregation. Whilst the chaperone activity of sHsps against amorphously aggregating proteins has been well studied, its action against fibril-forming proteins has received less attention despite the presence of sHsps in deposits found in fibril-associated diseases (e.g. Alzheimer's and Parkinson's). In this review, the literature on the interaction of αB-crystallin and other sHsps with fibril-forming proteins is summarized. In particular, the ability of sHsps to prevent fibril formation, their mechanisms of action and the possible in vivo consequences of such associations are discussed. Finally, the fibril-forming propensity of the crystallin proteins and its implications for cataract formation are described along with the potential use of fibrillar crystallin proteins as bionanomaterials.
Publisher
Basel : Birkhäuser-Verlag,Birkhäuser-Verlag,Springer Nature B.V
Subject
/ Alexander Disease - metabolism
/ alpha-Crystallin B Chain - chemistry
/ alpha-Crystallin B Chain - metabolism
/ alpha-Crystallin B Chain - physiology
/ Alzheimer Disease - metabolism
/ Amyloid
/ Biomedical and Life Sciences
/ cataract
/ Creutzfeldt-Jakob Syndrome - metabolism
/ Fibrils
/ Heat-Shock Proteins, Small - metabolism
/ Heat-Shock Proteins, Small - physiology
/ Humans
/ Lens
/ Lens, Crystalline - metabolism
/ Protein Processing, Post-Translational
/ Proteins
/ Review
