Journal Article

Correction: Multivalent Presentation of MPL by Porous Silicon Microparticles Favors T Helper 1 Polarization Enhancing the Anti-Tumor Efficacy of Doxorubicin Nanoliposomes

Yokoi, Kenji, Rhudy, Jessica R., Lavelle, Ed C., Savage, David J., Serda, Rita E., Meraz, Ismail M., Yang, Marie, Williams, Laura, Gu, Jianhua, Hearnden, Claire H., Liu, Xuewu

2024

Overview

Mice were evaluated for tumor size (calipers) and signs of distress (coat appearance, activity level, weight loss, shaking or posture changes). Combination therapy is superior to single agent therapy in a mouse model of breast cancer. a) 4T1 tumor growth in BALB/c mice was monitored using calipers. Control verses MPL-pSi, *p<0.05, n  =  3–5/group. b) Final mass of excised tumor. c) Images showing the relative size of extracted tumors and spleens. d) Mice were imaged weekly using the IVIS imaging system five min following injection with luciferin. e) Caliper-derived tumor volume measurements over time for BALB/c mice treated intravenously with low dose DOX-NPs in the presence or absence of MPL-pSi microparticles (5×108) (time of microparticle injections indicated by arrows; DOX-NPs verses DOX-NPs plus MPL-pSi, *p<0.05, n  =  3–4/group). f) Final weights of excised tumors, *p<0.05. g) Relative size of excised tumors and spleens. h) Weekly IVIS imaging of mice injected with luciferin. i) Quantitation of the bioluminescence data is presented as total flux in protons/sec. j) Increase in tumor growth blockade due to MPL-pSi microparticles (red) over that induced by DOX-NPs (blue) shown graphically across time. k) Similar to A & E, 4T1 tumor growth was monitored in BALB/c mice using calipers.

• Publisher: Public Library of Science,Public Library of Science (PLoS)