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Effects of silver nanoparticles in combination with antibiotics on the resistant bacteria Acinetobacter baumannii
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Effects of silver nanoparticles in combination with antibiotics on the resistant bacteria Acinetobacter baumannii
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Journal Article
Effects of silver nanoparticles in combination with antibiotics on the resistant bacteria Acinetobacter baumannii
2016
Overview
Acinetobacter baumannii resistance to carbapenem antibiotics is a serious clinical challenge. As a newly developed technology, silver nanoparticles (AgNPs) show some excellent characteristics compared to older treatments, and are a candidate for combating A. baumannii infection. However, its mechanism of action remains unclear. In this study, we combined AgNPs with antibiotics to treat carbapenem-resistant A. baumannii (aba1604). Our results showed that single AgNPs completely inhibited A. baumannii growth at 2.5 μg/mL. AgNP treatment also showed synergistic effects with the antibiotics polymixin B and rifampicin, and an additive effect with tigecyline. In vivo, we found that AgNPs-antibiotic combinations led to better survival ratios in A. baumannii-infected mouse peritonitis models than that by single drug treatment. Finally, we employed different antisense RNA-targeted Escherichia coli strains to elucidate the synergistic mechanism involved in bacterial responses to AgNPs and antibiotics.
Publisher
Dove Medical Press Limited,Taylor & Francis Ltd,Dove Press,Dove Medical Press
Subject
/ Acinetobacter baumannii - drug effects
/ Acinetobacter baumannii - isolation & purification
/ Acinetobacter baumannii - pathogenicity
/ Acinetobacter Infections - drug therapy
/ AgNPs
/ Animals
/ Anti-Bacterial Agents - chemistry
/ Anti-Bacterial Agents - pharmacology
/ Bacteria
/ beta-Lactam Resistance - drug effects
/ E coli
/ Ethics
/ Humans
/ Male
/ Metal Nanoparticles - chemistry
/ Rifampin
/ Silver
