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A glimpse into viral warfare: decoding the intriguing role of highly pathogenic coronavirus proteins in apoptosis regulation
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A glimpse into viral warfare: decoding the intriguing role of highly pathogenic coronavirus proteins in apoptosis regulation
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Journal Article
A glimpse into viral warfare: decoding the intriguing role of highly pathogenic coronavirus proteins in apoptosis regulation
2024
Overview
Coronaviruses employ various strategies for survival, among which the activation of endogenous or exogenous apoptosis stands out, with viral proteins playing a pivotal role. Notably, highly pathogenic coronaviruses such as SARS-CoV-2, SARS-CoV, and MERS-CoV exhibit a greater array of non-structural proteins compared to low-pathogenic strains, facilitating their ability to induce apoptosis via multiple pathways. Moreover, these viral proteins are adept at dampening host immune responses, thereby bolstering viral replication and persistence. This review delves into the intricate interplay between highly pathogenic coronaviruses and apoptosis, systematically elucidating the molecular mechanisms underpinning apoptosis induction by viral proteins. Furthermore, it explores the potential therapeutic avenues stemming from apoptosis inhibition as antiviral agents and the utilization of apoptosis-inducing viral proteins as therapeutic modalities. These insights not only shed light on viral pathogenesis but also offer novel perspectives for cancer therapy.
Highlights
• Apoptosis plays an important role in the pathogenesis of the highly pathogenic coronavirus
• The structural and non-structural proteins of highly pathogenic coronaviruses exert significant influence over apoptosis regulation
• Apoptosis inhibitors exhibits promising antiviral effects, thereby presenting a potential avenue for the development of novel therapeutics targeting COVID-19.
Publisher
BioMed Central,BioMed Central Ltd,Springer Nature B.V,BMC
Subject
/ B cells
/ Biomedical and Life Sciences
/ COVID-19
/ Highly Pathogenic Coronavirus
/ Humans
/ Kinases
/ Middle East respiratory syndrome
/ Middle East Respiratory Syndrome Coronavirus - physiology
/ Proteins
/ Review
/ Severe acute respiratory syndrome coronavirus 2
/ Severe acute respiratory syndrome-related coronavirus - physiology
/ Viruses
