Asset Details
Do you wish to reserve the book?
Geospatial environmental complexity, spatial brain volume, and spatial behavior across the Alzheimer's disease spectrum
Hey, we have placed the reservation for you!
By the way, why not check out events that you can attend while you pick your title.
Oops! Something went wrong.
Looks like we were not able to place the reservation. Kindly try again later.
Are you sure you want to remove the book from the shelf?
Geospatial environmental complexity, spatial brain volume, and spatial behavior across the Alzheimer's disease spectrum
Do you wish to request the book?
Geospatial environmental complexity, spatial brain volume, and spatial behavior across the Alzheimer's disease spectrum
Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy
We have requested the book for you!
Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.
Oops! Something went wrong.
Looks like we were not able to place your request. Kindly try again later.
Journal Article
Geospatial environmental complexity, spatial brain volume, and spatial behavior across the Alzheimer's disease spectrum
2024
Overview
INTRODUCTION Understanding impact of environmental properties on Alzheimer's disease (AD) is paramount. Spatial complexity of one's routinely navigated environment is an important but understudied factor. METHODS A total of 660 older adults from National Alzheimer's Coordinating Center (NACC) dataset were geolocated and environmental complexity index derived from geospatial network landmarks and points‐of‐interest. Latent models tested mediation of spatial navigation‐relevant brain volumes and diagnosis (cognitively‐healthy, mild cognitive impairment [MCI], AD) on effect of environmental complexity on spatial behavior. RESULTS Greater environmental complexity was selectively associated with larger allocentric (but not egocentric) navigation‐related brain volumes, lesser diagnosis of MCI and AD, and better spatial behavioral performance, through indirect hierarchical mediation. DISCUSSION Findings support hypothesis that spatially complex environments positively impact navigation neural circuitry and spatial behavior function. Given the vulnerability of these very circuits to AD pathology, residing in spatially complex environments may be one factor to help stave off the brain atrophy that accompanies spatial navigation deficits across the AD spectrum.
Publisher
John Wiley and Sons Inc,Wiley
