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Mesenchymal stromal cells＇ role in tumor microenvironment：involvement of signaling pathways
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Mesenchymal stromal cells＇ role in tumor microenvironment：involvement of signaling pathways
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Journal Article
Mesenchymal stromal cells＇ role in tumor microenvironment：involvement of signaling pathways
2017
Overview
Mesenchymal stromal cells（MSCs） are adult multipotent stem cells residing as pericytes in various tissues and organs where they can differentiate into specialized cells to replace dying cells and damaged tissues. These cells are commonly found at injury sites and in tumors that are known to behave like ＂wounds that do not heal.＂ In this article, we discuss the mechanisms of MSCs in migrating, homing, and repairing injured tissues. We also review a number of reports showing that tumor microenvironment triggers plasticity mechanisms in MSCs to induce malignant neoplastic tissue formation, maintenance, and chemoresistance, as well as tumor growth. The antitumor properties and therapeutic potential of MSCs are also discussed.
Publisher
Department of Biomedical Sciences, University of Ngaoundere, Ngaoundere 454, Cameroon%Laboratory, University of Verona, Verona 37129, Italy%Department of Basic, Health Sciences, College of Applied Medical Sciences, Qassim University,Buraydah 52571, Saudi Arabia%Faculty of Science, University of Poitiers, Poitiers 86022, France%Department of Biochemistry, College of Medicine, University of Saskatchewan, Saskatoon S7N 5E5, Canada,Cancer Biology & Medicine,Chinese Anti-Cancer Association,China Anti-Cancer Association
