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A randomised, assessor blind, parallel group comparative efficacy trial of three products for the treatment of head lice in children - melaleuca oil and lavender oil, pyrethrins and piperonyl butoxide, and a \suffocation\ product
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A randomised, assessor blind, parallel group comparative efficacy trial of three products for the treatment of head lice in children - melaleuca oil and lavender oil, pyrethrins and piperonyl butoxide, and a \suffocation\ product
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A randomised, assessor blind, parallel group comparative efficacy trial of three products for the treatment of head lice in children - melaleuca oil and lavender oil, pyrethrins and piperonyl butoxide, and a \suffocation\ product
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Journal Article
A randomised, assessor blind, parallel group comparative efficacy trial of three products for the treatment of head lice in children - melaleuca oil and lavender oil, pyrethrins and piperonyl butoxide, and a \suffocation\ product
2010
Overview
Background
There are many different types of pediculicides available OTC in Australia. In this study we compare the efficacy and safety of three topical pediculicides: a pediculicide containing melaleuca oil (tea tree oil) and lavender oil (TTO/LO); a head lice \"suffocation\" product; and a product containing pyrethrins and piperonyl butoxide (P/PB).
Method
This study was a randomised, assessor-blind, comparative, parallel study of 123 subjects with live head lice. The head lice products were applied according to the manufacturer's instructions (the TTO/LO product and the \"suffocation\" product were applied three times at weekly intervals according to manufacturers instructions (on Day 0, Day 7 and Day 14) and the P/PB product was applied twice according to manufacturers instructions (on Day 0 and Day 7)). The presence or absence of live lice one day following the last treatment was determined.
Results
The percentage of subjects who were louse-free one day after the last treatment with the product containing tea tree oil and lavender oil (41/42; 97.6%) and the head lice \"suffocation\" product (40/41, 97.6%) was significantly higher compared to the percentage of subjects who were louse-free one day after the last treatment with the product containing pyrethrins and piperonyl butoxide (10/40, 25.0%; adj. p < 0.0001).
Conclusion
The high efficacy of the TTO/LO product and the head lice \"suffocation\" product offers an alternative to the pyrethrins-based product.
Trial Registration
The study was entered into the Australian/New Zealand Clinical Trial Registry, ACTRN12610000179033.
Publisher
BioMed Central,BioMed Central Ltd
Subject
/ Anti-Infective Agents, Local - administration & dosage
/ Anti-Infective Agents, Local - adverse effects
/ Asphyxia
/ Child
/ Humans
/ Insecticides - administration & dosage
/ Insecticides - adverse effects
/ Lice
/ Lice Infestations - drug therapy
/ Medicine
/ Oils, Volatile - administration & dosage
/ Oils, Volatile - adverse effects
/ Pesticide Synergists - administration & dosage
/ Pesticide Synergists - adverse effects
/ Piperonyl Butoxide - administration & dosage
/ Piperonyl Butoxide - adverse effects
/ Plant Oils - administration & dosage
/ Plant Oils - adverse effects
/ Pyrethrins - administration & dosage
/ Pyrethrins - adverse effects
/ Tea Tree Oil - administration & dosage
