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Abundance of Ribosomal RNA Gene Copies Maintains Genome Integrity
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Journal Article
Abundance of Ribosomal RNA Gene Copies Maintains Genome Integrity
2010
Overview
The ribosomal RNA (rDNA) gene repeats are essential housekeeping genes found in all organisms. A gene amplification system maintains large cluster(s) of tandemly repeated copies in the chromosome, with each species having a specific number of copies. Yeast has many untranscribed rDNA copies (extra copies), and we found that when they are lost, the cells become sensitive to DNA damage induced by mutagens. We show that this sensitivity is dependent on rDNA transcriptional activity, which interferes with cohesion between rDNA loci of sister chromatids. The extra rDNA copies facilitate condensin association and sister-chromatid cohesion, thereby facilitating recombinational repair. These results suggest that high concentrations of heavily transcribed genes are toxic to the cells, and therefore amplified genes, such as rDNA, have evolved.
Publisher
American Association for the Advancement of Science,The American Association for the Advancement of Science
Subject
Adenosine Triphosphatases - metabolism
/ Biological and medical sciences
/ Cell Cycle Proteins - metabolism
/ Chromosomal Proteins, Non-Histone - metabolism
/ Chromosomes, Fungal - genetics
/ Chromosomes, Fungal - physiology
/ Cohesins
/ Cohesion
/ DNA
/ DNA-Binding Proteins - metabolism
/ Fundamental and applied biological sciences. Psychology
/ Gels
/ Genes
/ Genomics
/ loci
/ Methyl Methanesulfonate - pharmacology
/ Molecular and cellular biology
/ Multiprotein Complexes - metabolism
/ Mutagens
/ RNA
/ Saccharomyces cerevisiae - drug effects
/ Saccharomyces cerevisiae - genetics
/ Saccharomyces cerevisiae - growth & development
/ Yeast
/ Yeasts
