Journal Article

Association of Intussusception and Celiac Disease in Adults

Lewis, Suzanne K, Gonda, Tamas A, Rubin, Moshe, Cheng, Jian, Khan, Sharif-Uz-Zaman, Green, Peter H. R

2010

Overview

Introduction Intussusception (IS) is rare in adults. However, the more frequent use of cross-sectional imaging has resulted in an increase in its detection. Because of the reported association with celiac disease, we determined the prevalence of IS among a cohort with celiac disease. Methods An anonymized prospectively maintained celiac disease database and radiological database were reviewed. Results Of a total of 880 patients, 14 (age 47 ± 17.5 years; 50% female) had IS that was detected by CT in 10, capsule endoscopy in three, and barium studies in two. The reason for evaluation was abdominal pain in 78% (11/14), whereas in the remainder (3/14) were incidental. IS was the initial manifestation of celiac disease in 57% (8/14). Two patients were found to have lead-point intussusceptions and both had small-bowel adenocarcinoma, and 10/14 had severe villous atrophy (subtotal or total). Among those with established celiac disease, IS was detected early, within 3 years of diagnosis. Follow-up was available for 11 patients, 9 of who adhered strictly to a gluten-free diet, and six had no recurrence. Among all the patients diagnosed with IS on radiologic studies at our institution, 45 were considered to have idiopathic IS. Only two of these patients had evaluation for celiac disease. Conclusion IS occurs in celiac disease. It may be the initial presentation and is associated with abdominal pain. Adenocarcinoma needs to be excluded. The majority of patients do not have recurrent symptoms after adherence to a gluten-free diet. Celiac disease should be considered more frequently when IS is encountered.

• Publisher: Boston : Springer US,Springer US,Springer,Springer Nature B.V
• Subject: Abdominal Pain - epidemiology / Abdominal Pain - pathology / Adenocarcinoma - epidemiology / Adenocarcinoma - pathology / Adult / Adults / Atrophy / Biochemistry / Biological and medical sciences / Biopsy / Capsule Endoscopy / Celiac disease / Celiac Disease - epidemiology / Celiac Disease - pathology / Chi-Square Distribution / Colorectal cancer / Databases, Factual / Feeding. Feeding behavior / Female / Follow-Up Studies / Fundamental and applied biological sciences. Psychology / Gastroenterology / Gastroenterology. Liver. Pancreas. Abdomen / Hepatology / Humans / Incidental Findings / Intestinal Neoplasms - epidemiology / Intestinal Neoplasms - pathology / Intussusception - epidemiology / Intussusception - pathology / Male / Medical research / Medical sciences / Medicine / Medicine & Public Health / Medicine, Experimental / Middle Aged / Oncology / Original Article / Other diseases. Semiology / Stomach. Duodenum. Small intestine. Colon. Rectum. Anus / Transplant Surgery / Vertebrates: anatomy and physiology, studies on body, several organs or systems