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肺癌驱动基因与PD-1/PD-L1信号通路相互作用在非小细胞肺癌发生发展中的研究进展
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肺癌驱动基因与PD-1/PD-L1信号通路相互作用在非小细胞肺癌发生发展中的研究进展
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肺癌驱动基因与PD-1/PD-L1信号通路相互作用在非小细胞肺癌发生发展中的研究进展
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Journal Article
肺癌驱动基因与PD-1/PD-L1信号通路相互作用在非小细胞肺癌发生发展中的研究进展
2017
Overview
程序性死亡分子1（programmed death 1,PD-1）/程序性死亡分子1配体（programmed death 1 ligand,PD-L1）通路是免疫调节的重要通路,而这一通路在肿瘤组织中存在着异常激活,提示PD-1/PD-L1通路可能参与了肿瘤的免疫逃逸过程。肿瘤驱动基因在非小细胞肺癌（non-small cell lung cancer,NSCLC）的发生发展中发挥着重要的作用,而对于肿瘤免疫逃逸的建立同样具有潜在的作用,这提示肿瘤驱动基因通路与PD-1/PD-L1通路可能存在相互作用。本文将对目前关于PD-L1与主要的肺癌驱动基因表皮生长因子受体基因（epidermal growth factor receptor,EGFR）、鼠类肉瘤病毒癌基因（Kirsten rate sarcoma viral oncogene homolog,KRAS）及棘皮微管样蛋白4-间变性淋巴瘤激酶融合基因（echinoderm microtubuleassociated protein-like 4-anaplastic lymphoma kinase,EML4-ALK）之间的关系及调控进行综述,总结肺癌驱动基因及PD-1/PD-L1通路相互作用在非小细胞肺癌发生发展中的作用。
Publisher
浙江大学附属第一医院胸外科, 杭州,310003
Subject
