Journal Article

The Electronic Medical Records and Genomics (eMERGE) Network: past, present, and future

Jarvik, Gail P., Larson, Eric B., Carey, David J., Gallego, Carlos J., Connolly, John J., McCarty, Catherine, Williams, Marc S., Faucett, W. Andrew, Chisholm, Rex L., Roden, Dan M., Hakonarson, Hakon, Smith, Maureen E., Sanderson, Saskia C., Kohane, Isaac, Li, Rongling, Tromp, Gerard, Kuivaniemi, Helena, Manolio, Teri A., Chute, Christopher G., Ritchie, Marylyn D., Denny, Joshua C., Haines, Jonathan L., Basford, Melissa A., Harley, John, Böttinger, Erwin P., Gottesman, Omri, Kannry, Joseph, Brilliant, Murray, Zinberg, Randi, Crosslin, David, Kullo, Iftikhar J.

2013

Overview

The Electronic Medical Records and Genomics Network is a National Human Genome Research Institute–funded consortium engaged in the development of methods and best practices for using the electronic medical record as a tool for genomic research. Now in its sixth year and second funding cycle, and comprising nine research groups and a coordinating center, the network has played a major role in validating the concept that clinical data derived from electronic medical records can be used successfully for genomic research. Current work is advancing knowledge in multiple disciplines at the intersection of genomics and health-care informatics, particularly for electronic phenotyping, genome-wide association studies, genomic medicine implementation, and the ethical and regulatory issues associated with genomics research and returning results to study participants. Here, we describe the evolution, accomplishments, opportunities, and challenges of the network from its inception as a five-group consortium focused on genotype–phenotype associations for genomic discovery to its current form as a nine-group consortium pivoting toward the implementation of genomic medicine. Genet Med15 10, 761–771.

• Publisher: Elsevier Inc,Nature Publishing Group US,Elsevier Limited,Nature Publishing Group
• Subject: Biomedical and Life Sciences / Biomedicine / collaborative research / Consortia / Electronic health records / Electronic Health Records - trends / electronic medical records / Genetic Research - ethics / genetics and genomics / genome-wide association studies / Genome-Wide Association Study / Genomes / Genomics / Genomics - ethics / Genomics - trends / Genotype / Human Genetics / Humans / Laboratory Medicine / Medical records / National Human Genome Research Institute (U.S.) / personalized medicine / Phenotype / Precision Medicine / Review / United States