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Triple-induction treatment for locally advanced non-small cell lung cancer: a case report of pathological complete response
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Triple-induction treatment for locally advanced non-small cell lung cancer: a case report of pathological complete response
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Journal Article
Triple-induction treatment for locally advanced non-small cell lung cancer: a case report of pathological complete response
2024
Overview
Background
In patients with resectable stage III non-small cell lung cancer (NSCLC), induction chemoimmunotherapy followed by surgical resection has shown unprecedented rates of pathological response and event-free survival. However, a triple-induction including radiochemotherapy and immunotherapy followed by surgical resection has not been routinely established in clinical practice.
Case presentation
We report the case of a 47-year-old patient with stage IIIA NSCLC who was treated in a combined concept including induction concurrent radiochemotherapy, followed by 4 cycles of pembrolizumab and subsequent intrapericardial left-sided pneumonectomy. Histological analysis revealed a pathological complete response.
Conclusions
The case demonstrates that the combination of neoadjuvant chemo-, radio- and immunotherapy in advanced NSCLC may lead to a relevant down-staging and may enable a R0-resection of a borderline resectable tumor. However, the combination of four different treatment modalities requires resilience and a good performance status. A triple induction treatment may be a promising option for selected patients with locally advanced NSCLC and good performance status.
Publisher
BioMed Central,BioMed Central Ltd,Springer Nature B.V,BMC
