Journal Article

Selective stimulation of rat sciatic nerve using an array of mm-size magnetic coils: a simulation study

Lazzi, Gianluca, Kosta, Pragya, Warren, David J.

2019

Overview

This work proposes and computationally investigate the use of magnetic neural stimulation as an alternative to electrical stimulation to achieve selective activation of rat sciatic nerve. In particular, they assess the effectiveness of an array of small coils to obtain selective neural stimulation, as compared to a single coil. Specifically, an array of four mm-sized coils is used to stimulate rat sciatic nerve, targeting the regions of fascicles that are associated with different muscles of the leg. To evaluate the selectivity of activation, a three-dimensional heterogeneous multi-resolution nerve model is implemented using the impedance method for the computation of the magnetic and electric fields in the nerve. The performance metric ‘selectivity index’ is defined that measures the recruitment of the targeted region compared to other non-targeted regions of the nerve. The selectivity index takes values between −1 (least selective) and 1 (most selective). For each targeted region, a selectivity index of 0.75 or better is predicted for the proposed array configuration. The results suggest that an array of coils can provide superior spatial control of the electric field induced in the neural tissue compared to traditional extraneural electrode arrays, thus opening the possibility to applications where selective neurostimulation is of interest.

• Publisher: The Institution of Engineering and Technology,John Wiley & Sons, Inc,Wiley
• Subject: array configuration / bioelectric phenomena / bioelectric potentials / biological tissues / biomagnetism / biomedical electrodes / Electric fields / electrical stimulation / Electrodes / Magnetic fields / magnetic neural stimulation / mm-size magnetic coils / muscle / Nervous system / neuromuscular stimulation / neurophysiology / nontargeted regions / performance metric / Permeability / physiological models / rat sciatic nerve / selective activation / selective neural stimulation / selective neurostimulation / selective stimulation / selectivity index / Simulation / single coil / targeted region / three-dimensional heterogeneous multiresolution nerve model / traditional extraneural electrode arrays