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Leishmaniasis: Vaccine candidates and perspectives
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Journal Article
Leishmaniasis: Vaccine candidates and perspectives
2012
Overview
► Drawbacks of chemotherapy calls for therapeutic alternative and vaccination. ► Complete genome sequence enlightens the design of vaccine candidates. ► Molecular targets for vaccine chosen according to their homology with the host. ► Candidates identified according to their ability to act as B or T-cell immunogen. ► Enthusiastic results with recombinant forms of candidates emphasize their use.
Leishmania is a protozoan parasite and a causative agent of the various clinical forms of leishmaniasis. High cost, resistance and toxic side effects of traditional drugs entail identification and development of therapeutic alternatives. The sound understanding of parasite biology is key for identifying novel drug targets, that can induce the cell mediated immunity (mainly CD4+ and CD8+ IFN-gamma mediated responses) polarized towards a Th1 response. These aspects are important in designing a new vaccine along with the consideration of the candidates with respect to their ability to raise memory response in order to improve the vaccine performance. This review is an effort to identify molecules according to their homology with the host and their ability to be used as potent vaccine candidates.
Publisher
Elsevier Ltd,Elsevier Limited
Subject
/ Antigens
/ CD4-Positive T-Lymphocytes - immunology
/ CD8-Positive T-Lymphocytes - immunology
/ DNA
/ Genomes
/ Humans
/ Interferon-gamma - secretion
/ Leishmaniasis - epidemiology
/ Leishmaniasis - prevention & control
/ Leishmaniasis Vaccines - administration & dosage
/ Leishmaniasis Vaccines - immunology
/ Studies
/ toxicity
/ Vaccine
/ Vaccines
/ Zoonoses
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