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ProGRP与NSE对小细胞肺癌诊断价值的meta分析
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ProGRP与NSE对小细胞肺癌诊断价值的meta分析
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Journal Article
ProGRP与NSE对小细胞肺癌诊断价值的meta分析
2010
Overview
背景与目的胃泌素释放肽前体（pro-gastrin-releasing peptide,ProGRP）和神经元特异性烯醇化酶（neuron specific enolase,NSE）是目前研究较多的小细胞肺癌（small cell lung cancer,SCLC）肿瘤标记物,本研究综合评价了二者对SCLC的诊断价值。方法检索Pubmed、OVID、Elsevier Sciencedirect、Springer、Cochrane Library、Em-base、IFCC、中国生物医学文献数据库和维普医药信息资源系统,收集血清ProGRP与NSE用于SCLC诊断的研究数据。通过meta分析拟合SROC曲线,合并诊断效应量,比较ProGRP和NSE对SCLC的诊断效能。结果本次meta分析共纳入10篇文献,累计病例2536例,其中SCLC935例,非小细胞肺癌（non-small cell lung cancer,NSCLC）1601例,对照849例。ProGRP和NSE的合并敏感度分别为0.70和0.61,合并特异度为0.93和0.90,合并阳性似然比为11.57和5.67,合并阴性似然比为0.32和0.45,合并诊断比值比为36.45和13.08。SROC曲线显示,ProGRP和NSE的Q＊统计量分别为0.8042和0.7232,但差异无统计学意义。结论 ProGRP对SCLC的鉴别能力与NSE相近,但特异度更高,可以作为SCLC的诊断指标。
Publisher
北京协和医学院中国医学科学院肿瘤医院肿瘤研究所,北京,100021
Subject
