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一线化疗方案治疗广泛期小细胞肺癌的网状meta分析
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一线化疗方案治疗广泛期小细胞肺癌的网状meta分析
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Journal Article
一线化疗方案治疗广泛期小细胞肺癌的网状meta分析
2016
Overview
背景与目的顺铂/卡波联合伊立替康/依托泊苷双药化疗方案被推荐为治疗广泛期小细胞肺癌（small cell lung cancer of extensive disease, ED-SCLC）的一线化疗方案。我们在网状meta分析中，通过合成直接证据和间接证据，对推荐的化疗方案的短期疗效进行排序。方法我们在EMBASE、PubMed、CENTARL及clinicaltrial.gov数据库检出了相关疗效比较的随机对照试验。ROB工具被用于评估纳入研究的质量， Stata 13.1被用于统计学合成。结果该研究共纳入10项随机对照研究，共计2,378名患者。与依托泊苷联合卡铂相比，肿瘤的完全缓解率（complete remission rate, CR）在伊立替康联合卡铂组明显提高（OR=3.33,95%CI：1.47-7.54, P〈0.05）。伊立替康联合卡铂治疗后CR明显优于依托泊苷联合顺铂（OR=4.09,95%CI：1.18-14.12, P〈0.05）。结论本研究结果显示：伊立替康联合卡铂一线治疗ED-SCLC的疗效优于依托泊苷。
